Mechanism of Hyperkalemia-Induced Metabolic Acidosis
نویسندگان
چکیده
منابع مشابه
Drug-Induced Metabolic Acidosis
Metabolic acidosis could emerge from diseases disrupting acid-base equilibrium or from drugs that induce similar derangements. Occurrences are usually accompanied by comorbid conditions of drug-induced metabolic acidosis, and clinical outcomes may range from mild to fatal. It is imperative that clinicians not only are fully aware of the list of drugs that may lead to metabolic acidosis but also...
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The widespread belief that intense exercise causes the production of “lactic acid” that contributes to acidosis is erroneous. In the breakdown of a glucose molecule to 2 pyruvate molecules, three reactions release a total of four protons, and one reaction consumes two protons. The conversion of 2 pyruvate to 2 lactate by lactate dehydrogenase (LDH) also consumes two protons. Thus lactate produc...
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The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate. On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, resulting in a decrease in cellular pH. These...
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During ischemia, lidocaine or quinidine may prevent arrhythmias by blocking conduction without suppressing abnormal automaticity. The purpose of this study was to determine whether lidocaine or quinidine (5 Mg/ml) produced Purkinje fiber-papillary muscle block during superfusion in vitro with an altered Tyrode's solution containing some components of ischemia: 6 mM potassium, Po2 < 40, pH = 6.8...
متن کاملEffects of hypoxia, hyperkalemia, and metabolic acidosis on canine subendocardial action potential conduction.
We have studied the individual and combined effects of elevated external potassium concentration (8 mM [K+], metabolic acidosis (pH = 6.8), and hypoxia at different stimulation 400 milliseconds) on Purkinje (P) and ventricular (V) conduction velocities and on Purkinje-ventricular junctional conduction delay (PVJ delay) in in vitro preparations from canine ventricles. Elevated [K+] had opposite ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2018
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2017111163